Patterns of Co-Occurring Gray Matter Concentration Loss across the Huntington Disease Prodrome
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چکیده
منابع مشابه
Patterns of Co-Occurring Gray Matter Concentration Loss across the Huntington Disease Prodrome
Huntington disease (HD) is caused by an abnormally expanded cytosine-adenine-guanine (CAG) trinucleotide repeat in the HTT gene. Age and CAG-expansion number are related to age at diagnosis and can be used to index disease progression. However, observed onset-age variability suggests that other factors also modulate progression. Indexing prodromal (pre-diagnosis) progression may highlight thera...
متن کاملLinking white matter and deep gray matter alterations in premanifest Huntington disease
Huntington disease (HD) is a fatal progressive neurodegenerative disorder for which only symptomatic treatment is available. A better understanding of the pathology, and identification of biomarkers will facilitate the development of disease-modifying treatments. HD is potentially a good model of a neurodegenerative disease for development of biomarkers because it is an autosomal-dominant disea...
متن کاملChapter 2 - Patterns of gray matter loss in different manifestations of Alzheimer ’ s disease
We assessed patterns of grey matter atrophy according to age-at-onset in a large sample of 215 AD patients and 129 controls with voxel-based morphometry using 3Tesla 3DT1 magnetic resonance imaging. Local grey matter amounts were compared between lateand early-onset AD patients and older and younger controls, taking into account the effect of APOE. Additionally, combined effects of age and diag...
متن کاملMagnetization transfer MR imaging demonstrates degeneration of the subcortical and cortical gray matter in Huntington disease.
BACKGROUND AND PURPOSE GM is typically affected in HD since the presymptomatic stage. Our aim was to investigate with MT MR imaging the microstructural changes of the residual brain subcortical and cortical GM in carriers of the HD gene and to preliminarily assess their correlation with the clinical features. MATERIALS AND METHODS Fifteen HD gene carriers with a range of clinical severity and...
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We detected and mapped a dynamically spreading wave of gray matter loss in the brains of patients with Alzheimer's disease (AD). The loss pattern was visualized in four dimensions as it spread over time from temporal and limbic cortices into frontal and occipital brain regions, sparing sensorimotor cortices. The shifting deficits were asymmetric (left hemisphere > right hemisphere) and correlat...
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ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2016
ISSN: 1664-2295
DOI: 10.3389/fneur.2016.00147